AusPharm Research Roundup is a weekly column collated by Debbie Rigby that is designed to bring AusPharmers a summary of selected research papers published during the preceding week or two.
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Nocturnal Leg Cramps and Prescription Use That Precedes Them: Archives of Internal Medicine
Lithium toxicity profile: a systematic review and meta-analysis: The Lancet
Treating Gout in Patients With Comorbidities: International Journal of Clinical Rheumatology
HbA1c and monitoring glycaemia: Australian Family Physician

Effect of Aspirin on Vascular and Nonvascular Outcomes: Archives of Internal Medicine
Dabigatran Association With Higher Risk of Acute Coronary Events: Archives of Internal Medicine
Risk of Mortality Among Individual Antipsychotics in Patients With Dementia: American Journal of Psychiatry
Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: Annals of Internal Medicine

Antihypertensive drugs and risk of incident gout among patients with hypertension: BMJ
Immediate and late benefits of treating very elderly people with hypertension: BMJ
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: BMJ
Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative: Archive of Internal Medicine

Interventions for the management of dry mouth: topical therapies: Cochrane Database of Systematic Reviews
Potentially Harmful Drug–Drug Interactions in the Elderly: American Journal of Geriatric Pharmacotherapy
Even more data on cardiovascular risks of NSAIDs: time to review prescribing: MeReC Monthly
The Benefits of Low-Dose Aspirin: Pharmacy Times

Effect of Vitamin D Supplementation on Muscle Strength, Gait and Balance in Older Adults: A Systematic Review and Meta-Analysis: Journal of the American Geriatrics Society
Subcutaneous Versus Sublingual Immunotherapy for Allergic Rhinitis and/or Asthma: Immunotherapy
Effect of Pioglitazone, Metformin, and the Combination of Both on Cardiovascular Risk: Cardiovasc Diabetol
Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: The Journal of the American Dental Association

Drug interaction alerts in software — what do general practitioners and pharmacists want?: Medical Journal of Australia
Adverse events from calcium supplementation: Journal of Bone and Mineral Research
Nocturnal Leg Cramps and Prescription Use That Precedes Them: Archives of Internal Medicine
Vitamin D and Calcium: Implications for Healthy Aging: Clinical Geriatrics

Appropriate primary prevention of cardiovascular disease: does this mean more or less statin use?: Australian Prescriber
Population-based study of erectile dysfunction and polypharmacy: BJUI
Chronic Disease Management for Tobacco Dependence: Archives of Internal Medicine
What’s in a name? Brand name confusion and generic medicines: Medical Journal of Australia

Emergency Hospitalizations for Adverse Drug Events in Older Americans: New England Journal of Medicine
Hip Fracture in Postmenopausal Women After Cessation of Hormone Therapy: Menopause
Reducing Excessive Gestational Weight Gain: Women's Health
Vitamin E and the Risk of Prostate Cancer: Journal of the American Medical Association

Relationship Between Vitamin D and Hyperglycemia in Older People From a Nationally Representative Population Survey: Journal of the American Geriatrics Society
Prospective Associations of Vitamin D With β-Cell Function and Glycemia: Diabetes
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: The Lancet
Long Term Omega-3 Polyunsaturated Fatty Acid Supplementation Reduces the Recurrence of Persistent Atrial Fibrillation after Electrical Cardioversion: Heart Rhythm

Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity: British Journal of clinical Pharmacology
Rheumatoid Arthritis and Pregnancy: Rheumatology
Daily or Intermittent Budesonide in Preschool Children with Recurrent Wheezing: New England Journal of Medicine
Current Understanding of Hepatic and Intestinal OATP-mediated Drug-drug Interactions: Expert Review of Clinical Pharmacology

Warfarin Dose Assessment Every 4 Weeks Versus Every 12 Weeks in Patients With Stable International Normalized Ratios: Ann Intern Med
Dosing Clopidogrel Based on CYP2C19 Genotype and the Effect on Platelet Reactivity in Patients With Stable Cardiovascular Disease: JAMA
The Association of Acetaminophen and Asthma Prevalence and Severity: Pediatrics
Treating chronic fatigue syndrome – a study into the scientific evidence for pharmacological treatments: Australian Family Physician

What patients want and need to know about atrial fibrillation: Journal of Multidisciplinary Healthcare
Stroke risk and NSAIDs: an Australian population-based study: MJA
Dietary fibre, whole grains, and risk of colorectal cancer: BMJ
Cardiovascular Disease Prevention in Women: What Not to Use: US Pharm

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses: BMJ
Over-the-counter β2-agonist purchase versus script: A cross-sectional study: Respiratory Medicine
Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women: Menopause
Statins and Intracerebral Hemorrhage: Circulation

Ageing well: Improving the management of patients with multiple chronic health problems: Australasian Journal on Ageing
Bedtime Dosing of Antihypertensive Medications Reduces Cardiovascular Risk in CKD: Journal of the American Society of Nephrology
Tooth whitening: Do at-home bleaching systems work, and what adverse effects could they have?: Informedhealth online
Maintenance Therapy for Rheumatoid Arthritis: US Pharm

ADHD: Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: Pediatrics
Blood Pressure Targets Recommended by Guidelines and Incidence of Cardiovascular and Renal Events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET): Circulation
Evidence-based guideline update: Treatment of essential tremor: Neurology
Dietary Supplements and Mortality Rate in Older Women: Archives of Internal Medicine

Cautions with codeine: Australian Presicriber
Review of dutasteride/tamsulosin fixed-dose combination for the treatment of benign prostatic hyperplasia: efficacy, safety, and patient acceptability: Patient Preference and Adherence
Symptomatic effect of chondroitin sulfate in hand osteoarthritis the finger osteoarthritis chondroitin treatment study: Arthritis & Rheumatism
The impact of anticholinergic burden in Alzheimer's Dementia: Age Ageing

Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: Journal of the American Medical Association
Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: PLoS Medicine
Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults: Journal of the American Geriatrics Society
Managing Menorrhagia: US Pharmacist

Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction: CMAJ
Risk of fractures with inhaled corticosteroids in COPD: Thorax
Adverse Drug Events Related to Ziprasidone: Pharmacotherapy
Anticholinergic Medication Use and Cognitive Impairment in the Older Population: Journal of the American Geriatrics Society

Effect of Paracetamol on International Normalized Ratio in Patients Receiving Warfarin Therapy: Pharmacotherapy
Cholesterol lowering medication: Patients’ knowledge, attitudes and experiences: Australian Family Physician
Fibromyalgia: Should we be testing and treating for vitamin D deficiency?: Australian Family Physician
Proton pump inhibitors: Uncommon adverse effects: Australian Family Physician

Risk of serious adverse cardiovascular events associated with varenicline: Canadian Medical Association Journal
Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion: Canadian Medical Association Journal
The use of dabigatran in general practice: a cautious approach is recommended: Best Practice Journal
The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis: The Journal of Clinical Endocrinology & Metabolism

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