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AusPharm Research Roundup is a weekly column collated by Debbie Rigby that is designed to bring AusPharmers a summary of selected research papers published during the preceding week or two.

AusPharm Research Roundup

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  1. 20/01/2009 :

    Cochrane Database of Systematic Reviews: Hawthorn extract for treating chronic heart failure
    JAMA: Treatment of Fibromyalgia Syndrome With Antidepressants
    Medscape: Does Vitamin B12 Help Relieve Fatigue?
    Diseases of the Colon and Rectum: Probiotics may improve irritable bowel syndrome.

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  2. 15/01/2009 :

    Journal of the American Dental Association: Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw
    Essential Evidence Plus: Benefit of low-dose aspirin for type 2 diabetes is uncertain
    MeReC: Lipid-modifying treatment
    Canadian Medical Journal: Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

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  3. 23/12/2008 :

    Annals of Internal Medicine: Alcohol Screening Scores and Medication Nonadherence
    The Lancet: Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    JAMA: Vitamins E and C and selenium are ineffective in preventing prostate cancer
    Canadian Medical Association Journal: Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

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  4. 15/12/2008 :

    US Pharmacist: SSRIs and Serotonin Syndrome
    US Pharmacist: Postpartum Depression
    Thorax: Varenicline similar in effectiveness to nicotine patch
    American Academy of Dermatology: Position Statement on vitamin D.

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  5. 09/12/2008 :

    Diabetes Care: Egg Consumption and Risk of Type 2 Diabetes in Men and Women
    Archives of Internal Medicine: Comparison of Cardiovascular Outcomes in Elderly Patients With Diabetes Who Initiated Rosiglitazone vs Pioglitazone Therapy
    Australian Prescriber: Hypnotic hazards: adverse effects of zolpidem and other z-drugs
    Australian Prescriber: Lifestyle management of hypertension

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  6. 01/12/2008 :

    MeReC Monthly: Anticholinergics in COPD — new data on cardiovascular safety
    Internal Medicine Journal: Patterns of glycaemic control in Australian primary care (NEFRON 8)
    Annals of Pharmacotherapy: Effects of Garlic on Blood Pressure in Patients With and Without Systolic Hypertension: A Meta-Analysis
    New England Journal of Medicine: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein (JUPITER trial).

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  7. 24/11/2008 :

    Archives of Internal Medicine: Calcium supplements in middle-aged men – higher but not lower doses increase BMD
    BMJ: Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis
    Journal of Clinical Endocrinology & Metabolism: Vitamin D Insufficiency Linked to Increased Body Fat
    JAMA: Ginkgo biloba for Prevention of Dementia.

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  8. 17/11/2008 :

    JAMA: Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes
    JAMA: Folic Acid and B Vitamins Ineffective for Cancer Prevention
    US Pharmacist: Drug-Induced Hypertension
    Medscape: Chondroitin and Glucosamine: Hype or Hope for Osteoarthritis?

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  9. 10/11/2008 :

    Journal for Nurse Practitioners: Walking the Tightrope: Chronic Pain and Substance Abuse
    Chest, Archives of Internal Medicine: Bisphosphonates May Increase Risk of Atrial Fibrillation
    Archives of Internal Medicine: Metformin May Reduce Cardiovascular Risk in Type 2 Diabetes
    British Medical Journal: Maternal caffeine intake during pregnancy and risk of fetal growth restriction.

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  10. 03/11/2008 :

    The Journal of Family Practice: Vasomotor symptoms: Managing the transition from perimenopause to postmenopause
    Current Clinical Practice: Initiating and intensifying therapy in type 2 diabetes: Managing the progressive nature of the disease
    Journal of the American College of Cardiology: Relation of Beta-Blocker-Induced Heart Rate Lowering and Cardioprotection in Hypertension
    Clinical Diabetes: Hypoglycemia.

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  11. 27/10/2008 :

    Australian Prescriber: How to treat hypercholesterolaemia
    Annals of Pharmacotherapy: Aspirin, Clopidogrel, and Warfarin: Is the Combination Appropriate and Effective or Inappropriate and Too Dangerous
    Journal of the American Pharmacists Association: The Medication Assessment Program: Comprehensive Medication Assessments for Persons Taking Multiple Medications for Chronic Diseases
    Archives of Neurology: Vitamin D Deficiency May Be More Common in Parkinson's Disease.

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  12. 20/10/2008 :

    Due to a 'technical error', instead of publishing this week's Research Roundup on Monday we republished last week's. Here is this week's now  

    Neurology: The diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review)
    Cochrane Database of Systematic Reviews: St John's wort for major depression
    Journal of Rheumatology: Factors affecting persistence with weekly bisphosphonates
    BMJ: The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.

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  13. 13/10/2008 :

    National Heart Foundation: Fish, fish oils, n-3 polyunsaturated fatty acids and cardiovascular health
    European Heart Journal: Hormone therapy and risk of myocardial infarction: a national register study
    ADRAC Bulletin: Fatal interactions and reactions with colchicine: beware CYP3A4 inhibitors
    Medical Journal of Australia: Topical ophthalmic medications: what potential for systemic side effects and interactions with other medications?

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  14. 06/10/2008 :

    American Family Physician: Recommendations Issued for Managing Mastitis in Mothers Breast-Feeding Their Infants
    JAMA: Inhaled Anticholinergics and Risk of Major Adverse Cardiovascular Events in Patients With Chronic Obstructive Pulmonary Disease
    Annnals of Internal Medicine: Risk for Death Associated with Medications for Recently Diagnosed Chronic Obstructive Pulmonary Disease
    Journal of Family Practice: The role of incretin therapy for type 2 diabetes in family medicine.

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  15. 01/10/2008 :

    BMJ: Adherence to Mediterranean diet and health status
    Medical Journal of Australia: A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial
    British Journal of Clinical Pharmacology: Red ginseng for treating erectile dysfunction: a systematic review
    New England Journal of Medicine: Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes

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  16. 22/09/2008 :

    The week’s special edition Research Roundup looks at the Lancet ‘paracetamol’ paper that’s causing all the fuss.

    Many thanks to Debbie Rigby for working this up over the weekend for us, including commenting on the study's relevance to practice.

    Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme


    Exposure to paracetamol during intrauterine life, childhood, and adult life may increase the risk of developing asthma. We studied 6–7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma.

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  17. 15/09/2008 :

    BMJ: Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
    New England Journal of Medicine: Analyses of Cancer Data from Three Ezetimibe Trials
    Archives of Internal Medicine: Postmenopausal Hormone Use and Symptoms of Gastroesophageal Reflux
    Arthritis Care and Research: Ibuprofen Use Increases Cardiovascular Risk but Not for All Older Patients

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  18. 08/09/2008 :

    Urologic Nursing: Urinary Incontinence in the Childbearing Woman
    Medscape: Is Penicillin Safe in a Patient Allergic to Cephalosporins?
    Medical Journal of Australia: Contemporary management of type 2 diabetes: blood glucose-lowering therapies and glycaemic targets
    Medical Journal of Australia: Migraine prophylaxis.

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  19. 01/09/2008 :

    Pharmacy and Therapeutics: The Pharmacological management of migraine part 2: preventative therapy
    Thorax: Patient adherence in COPD
    JAMA: Nut, Corn, and Popcorn Consumption and the Incidence of Diverticular Disease
    BMJ: Health related quality of life after combined hormone replacement therapy.

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  20. 25/08/2008 : Journal of Family Practice: Obstructive sleep apnoea: recognition and management in primary care
    National Electronic Library for Medicines: What is the sodium content of medicines?
    New England Journal of Medicine: The Effects of Tibolone in Older Postmenopausal Women
    Annals of Internal Medicine: Low serum vitamin D levels associated with increased fracture risk?
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